Xiaolei Shi PhD MSc

trainee patent attorney

Xiaolei Shi

Professional field:
Biotechnology, medicine, medical technology, transplantation, immunology, microbiology, pharmacy

Shanghai Jiao Tong University (MD, medicine), Erasmus University Rotterdam (MSc, infection & immunity; PhD, transplant immunology)

In 2016, Xiaolei started working as a trainee patent agent for Arnold & Siedsma. He has extensive hands-on research experience in various biomedical fields. While pursuing his doctorate and master degree at Erasmus University Medical Center, he developed a state-of-the-art technique for immune monitoring, and studied the immunological and viral mechanisms involved in transplant tolerance. His work resulted in various publications, and was awarded the van Rood Award by the Nederlandse Transplantatie Vereniging. His research experience also includes the secretion system of Escherichia coli, when he worked as a student research assistant during medical school, as well as the pathogenesis of colorectal cancer, when he studied at the University of Michigan as an exchange student.

Thanks to his growing interest in technology innovation and commercial world over the years, Xiaolei pursues his career in intellectual property at Arnold & Siedsma, where he will also be involved in the business development in China.

Other People about Xiaolei:
Creative, critical, bold, broad range of interest

Work experience:
2016 - present: Trainee patent attorney at Arnold & Siedsma

2011 - 2016: Erasmus University Medical Center, PhD transplant immunology
2011 - 2013: Erasmus University Medical Center, MSc infection & immunity
2006 - 2011: Shanghai Jiao Tong University School of Medicine, MD clinical medicine

English, Chinese, Dutch (elementary)


  • Shi XL, Mancham S, Hansen BE, de Knegt RJ, et al. Interplay between donor PD-L1 and recipient PD-1 regulates acute graft rejection after liver transplantation. J Hepatol. 2016 Jun;64(6):1274-82. doi: 10.1016/j.jhep.2016.02.034. Epub 2016 Mar 3.
  • Shi XL, de Mare-Bredemeijer EL, Tapirdamaz O, Hansen BE, et al. CMV primary infection is associated with donor-specific T cell hyporesponsiveness and fewer late acute rejections after liver transplantation. Am J Transplant. 2015. Sep;15(9):2431-42.
  • de Mare-Bredemeijer ELD, Shi XL, Mancham S, van Gent R, et al. CMV-induced expression of CD244 after liver transplantation is associated with CD8+ T-cell hyporesponsiveness to allo-antigen. J Immunol. 2015. Aug 15;195(4):1838-48.
  • Shi XL, Moroso V, Metselaar HJ, Kwekkeboom J. Long-lived intragraft donor leukocytes or relocated donor hematopoietic stem/progenitor cells can cause long-term hematopoietic chimerism after liver transplantation. Hepatology. 2013; 57(6): 2542.
  • Shi XL, Chen XX, Jin R, Li H, et al. Polyclonal antibodies preparation of the Escherichia coli type VI secretion system related proteins and detection of secreted proteins. Journal of Shanghai Jiaotong University(Medical Science). 2011; 31(1): 118-22.

Telephone: +31 70 365 48 33